Comparative study on the immunosuppressive and lympholytic activity of optical isomers of cyclophosphamide.
Arch Immunol Ther Exp (Warsz)
; 31(3): 329-33, 1983.
Article
em En
| MEDLINE
| ID: mdl-6228204
ABSTRACT
The influence of chirality of cyclophosphamide (Cy) on the reactivity of lymphoid cells in vivo was studied in Balb/c mice. It has been shown that (+) Cy inhibits the formation of direct PFC in Balb/c mice more effectively than (-) Cy. The augmentation of DTH--reaction against HuRBC in mice, measured by the foot-pad test and the elongation of graft survival time were noted when racemic or (-) Cy were applied. Investigated forms of Cy decreased the number of nucleated cells in mice spleens, but lympholytic effect of (+) Cy was lower than that of racemic and (-) Cy. The possible consequences of stereo-differentiated immunosuppressive activity of enantiomeric forms of cyclophosphamide in the experimental procedures and the therapy of "autoimmune" and malignant diseases are considered.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos
/
Ciclofosfamida
/
Imunossupressores
Limite:
Animals
Idioma:
En
Revista:
Arch Immunol Ther Exp (Warsz)
Ano de publicação:
1983
Tipo de documento:
Article