Adrenocorticotropin deficiency: correction of hyponatremia and hypoaldosteronism with chronic glucocorticoid therapy.
J Clin Endocrinol Metab
; 50(1): 10-4, 1980 Jan.
Article
em En
| MEDLINE
| ID: mdl-6243127
ABSTRACT
A 36-yr-old woman with a chronic wasting illness associated with hyponatremia and hypotension proved to have secondary adrenal insufficiency and low levels of GH and PRL. TSH, LH, and FSH responses remained normal. Aldosterone excretion was markedly reduced (0.74 microgram/day) before replacement therapy was started, but normal renin and aldosterone responses to sodium restriction were observed after 6 months of corticosteroid treatment. These responses were maintained after acute steroid withdrawal despite the continued absence of ACTH. Chronically adequate glucocorticoid levels were necessary to maintain a normal aldosterone response in this patient. If there is also a pituitary factor required for this response, it does not appear to be ACTH.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dexametasona
/
Fludrocortisona
/
Hormônio Adrenocorticotrópico
/
Aldosterona
/
Hiponatremia
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
1980
Tipo de documento:
Article