Morphine in cow and human milk: could dietary morphine constitute a ligand for specific morphine (mu) receptors?
Science
; 213(4511): 1010-2, 1981 Aug 28.
Article
em En
| MEDLINE
| ID: mdl-6267691
ABSTRACT
Morphine has been found in cow and human milk at concentrations of 200 to 500 nanograms per liter. Multistep purification yields a material that has immunological, biological, pharmacological, and chemical properties identical to those of morphine. Similar morphine-like material, which has been tentatively identified in some common plant sources, may be a ubiquitous dietary constituent and a possible source for the material in milk. Since morphine (mu) receptors have a low affinity for enkephalins, and since morphine-like materials have been described in brain and intestine, it is possible that morphine in food may be the source of this material and a normal ligand specific for mu receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Opioides
/
Leite
/
Morfina
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1981
Tipo de documento:
Article