Involvement of polyADP-ribose polymerase in the initiation of phytohemagglutinin induced human lymphocyte proliferation.
Biochem Biophys Res Commun
; 116(2): 428-34, 1983 Oct 31.
Article
em En
| MEDLINE
| ID: mdl-6316953
ABSTRACT
Nicotinamide (10 mM) or 3-aminobenzamide (5 mM) added at the onset of phytohemagglutinin (PHA) treated human lymphocyte cultures provoke a marked inhibition of the PHA induced DNA synthesis and cell proliferation as well as of poly(ADPR) polymerase activity. When the inhibitors of poly(ADPR) polymerase are added at a later stage of culture (48 h) no inhibition of the stimulation of DNA synthesis and cell proliferation by PHA in human lymphocyte cultures is observed. The intervention of ADP ribosylation at the initiation of DNA synthesis is suggested.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fito-Hemaglutininas
/
Ativação Linfocitária
/
Poli(ADP-Ribose) Polimerases
/
NAD/ Nucleosidase
Limite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1983
Tipo de documento:
Article