The reversal of myelofibrosis associated with chronic myelogenous leukemia after allogeneic bone marrow transplantation.
Exp Hematol
; 11(7): 681-5, 1983 Aug.
Article
em En
| MEDLINE
| ID: mdl-6350032
ABSTRACT
A 20-year-old male with chronic myelogenous leukemia (CML) and severe bone marrow fibrosis underwent splenectomy, then ablative chemotherapy, followed by bone marrow transplantation from a histocompatible sister. The myelofibrosis completely resolved. Prompt marrow engraftment and disappearance of Philadelphia chromosome positive cells were documented. Therefore, the presence of marrow fibrosis which frequently accompanies CML is rapidly reversible following high dose chemotherapy and is not indicative of a hostile microenvironment which could preclude marrow transplantation for patients with CML and myelofibrosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide
/
Transplante de Medula Óssea
/
Mielofibrose Primária
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Exp Hematol
Ano de publicação:
1983
Tipo de documento:
Article