Pancreatic alpha cell autoantibodies and glucagon response to arginine.
Diabetes
; 33(5): 435-7, 1984 May.
Article
em En
| MEDLINE
| ID: mdl-6373451
ABSTRACT
The frequency and significance of cytoplasmic pancreatic alpha cell autoantibodies (ACA) were investigated in 2102 healthy controls, 879 patients with insulin-dependent diabetes mellitus (IDDM) who were negative for islet cell autoantibodies (ICA), and 1567 relatives of IDDM patients. ACA were found in approximately 1 in 200 people of all ages and were not significantly associated with IDDM, the IDDM-associated HLA phenotypes DR3 and DR4, or thyrogastric or adrenal autoantibodies. Of 11 ACA-positive patients studied by arginine stimulation tests, none had frank glucagon deficiency. Thus, ACA do not appear to be associated with defective alpha cell function or with IDDM.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Autoanticorpos
/
Glucagon
/
Ilhotas Pancreáticas
/
Diabetes Mellitus Tipo 1
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Diabetes
Ano de publicação:
1984
Tipo de documento:
Article