Direct inhibitory effect of gonadotropin releasing hormone in the uterus of rat.
Life Sci
; 34(23): 2257-63, 1984 Jun 04.
Article
em En
| MEDLINE
| ID: mdl-6374349
ABSTRACT
Estradiol induced increase in ornithine decarboxylase (ODC) and glucosamine-6-phosphate synthase activities of rat uterus were inhibited by simultaneous treatment with gonadotropin releasing hormone (GnRH) or its agonists. The direct inhibitory effect of GnRH analogs was found to be dose dependent. It was observed that a higher dose of GnRH analog was needed to cause inhibition of glucosamine-6-phosphate synthase when compared to ODC activity. The inhibitory effect of GnRH was not observed if its injection was delayed following estradiol treatment. These results show that the extra-pituitary inhibitory effects of GnRH involves enzymes associated with cell proliferation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Útero
/
Hormônios Liberadores de Hormônios Hipofisários
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1984
Tipo de documento:
Article