[Comparison of serum and prostatic levels of tobramycin]. / Comparaison des taux sériques et prostatiques de la tobramycine.

In 19 patients with various prostatic diseases, serum and prostatic tissue levels of tobramycin were determined by bioassay and enzyme immunoassay after 1, 3 or 4 intramuscular injections of 75 mg tobramycin. The last injection was given ninety minutes prior to prostatectomy. Mean serum and prostatic tissue levels were respectively 3.55 micrograms/ml and 1.70 micrograms/g by bioassay, and 3.55 micrograms/ml and 2.37 micrograms/g by enzyme immunoassay. There was no significant difference in prostatic tissue levels between patients who received 3 or 4 drug doses and those who received one dose. Prostatic tissue levels were not significantly different in adenoma and chronic prostatitis.