Poly(ADP-ribose) metabolism appears normal in EM9, a mutagen-sensitive mutant of CHO cells.
Mutat Res
; 128(2): 213-20, 1984 Sep.
Article
em En
| MEDLINE
| ID: mdl-6472314
ABSTRACT
EM9 is a mutagen-sensitive CHO cell whose phenotype resembles that of normal CHO cells exposed to 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthesis. This phenotype suggested that EM9 might be defective in poly(ADP-ribose) metabolism, but we now cannot find any abnormality in the synthesis or in the degradation of poly(ADP-ribose) in permeabilized EM9 cells. Thus the effects of 3-aminobenzamide on wild-type cells may be due to the inhibition of processes other than poly(ADP-ribose) synthesis. 3-Aminobenzamide enhances the cytotoxicity of EMS toward EM9 and control cells to the same degree.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poli Adenosina Difosfato Ribose
/
Mutagênicos
/
Mutação
/
Açúcares de Nucleosídeo Difosfato
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1984
Tipo de documento:
Article