Functional and biochemical indicators of pneumoconiosis in mice: comparison with rats.
J Toxicol Environ Health
; 13(4-6): 487-97, 1984.
Article
em En
| MEDLINE
| ID: mdl-6492183
ABSTRACT
Mice were injected intratracheally with silica or Mt. St. Helens volcanic ash (0.2 mg/g body weight) and examined 6 mo later for changes in pulmonary function, histology, and hydroxyproline content. Results were compared with a similar study using rats. Mice injected with volcanic ash showed significant changes only in wet lung weights. Those injected with silica showed an approximate doubling of lung wet weight and dry weight and hydroxyproline content. Larger increases in lung weight were seen if lymph nodes were left attached. Lung compliance, total lung capacity, and the shape of the pressure-volume curve of the lung were changed as much as 22% in the silica-treated mice. A mild degree of fibrosis with no dense lung consolidation was noted microscopically in silica-treated mice. In contrast, silica-treated rats showed dense lung consolidation, threefold to fivefold increases in both wet and dry lung weights and hydroxyproline content, and up to 40% reductions in pulmonary function measurements. It is concluded that Swiss albino mice develop a milder degree of fibrosis than similarly treated Sprague-Dawley rats and that both biochemical and functional indicators are effective in detecting pneumoconiosis in these species.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumoconiose
/
Modelos Animais de Doenças
/
Camundongos
Limite:
Animals
Idioma:
En
Revista:
J Toxicol Environ Health
Ano de publicação:
1984
Tipo de documento:
Article