Simple synthesis of F-18-labeled 2-fluoro-2-deoxy-D-glucose: concise communication.
J Nucl Med
; 25(3): 333-7, 1984 Mar.
Article
em En
| MEDLINE
| ID: mdl-6699724
ABSTRACT
Fluorine-18 acetyl hypofluorite, produced by a gas/solid-phase reaction, was reacted with D-glucal in water, followed by treatment with HCl and serial passage through columns of charcoal, ion-retardation resin, and alumina. The product was an injectable solution of 2-[18F]fluoro-2-deoxy-D-glucose. The radiochemical purity was greater than 95% and the radiochemical yield was about 40%. The synthesis was completed in about 15 min. Acetyl hypofluorite was shown to be a stable, highly stereoselective fluorinating agent in aqueous systems over a wide pH range.
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Base de dados:
MEDLINE
Assunto principal:
Radioisótopos
/
Desoxiaçúcares
/
Desoxiglucose
/
Ésteres
/
Flúor
/
Acetatos
Idioma:
En
Revista:
J Nucl Med
Ano de publicação:
1984
Tipo de documento:
Article