Evidence of excessive androgen secretion by both the ovary and the adrenal in patients with idiopathic hirsutism.
Obstet Gynecol
; 59(1): 46-51, 1982 Jan.
Article
em En
| MEDLINE
| ID: mdl-6804896
ABSTRACT
Fifteen patients with idiopathic hirsutism, who had no attenuated adrenal hyperplasia, obesity, enlarged ovaries, or amenorrhea, were studied. Excessive androgen secretion by adrenal tissue was suggested by the finding of increased levels of dehydroepiandrosterone sulfate, which decreased after dexamethasone administration but did not change after human chorionic gonadotropin (hCG) injection. Excessive androgen secretion by ovarian tissue was suggested by the finding that testosterone and androstenedione levels were elevated, correlated significantly with the levels of luteinizing hormone, decreased with administration of estrogen-progestagen, and increased after hCG injection. Notably, free testosterone levels, which were significantly increased, were only partially suppressed during dexamethasone or estrogen-progestagen administration. These results provide further evidence that both the adrenals and the ovaries secrete androgens excessively in patients with idiopathic hirsutism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Glândulas Suprarrenais
/
Hirsutismo
/
Androgênios
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Obstet Gynecol
Ano de publicação:
1982
Tipo de documento:
Article