Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.
Science
; 218(4572): 585-7, 1982 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-6812220
ABSTRACT
A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly. The primary structure of the tumor-derived peptide is H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala- Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly -Ala-Arg-Ala-Arg-Leu-NH2. The synthetic replicate has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone. The tumor-derived peptide is identical in biological activity and similar in physiochemical properties to the still uncharacterized growth hormone-releasing factor present in extracts of hypothalamic tissues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Acromegalia
/
Hormônio Liberador de Hormônio do Crescimento
/
Hormônios Ectópicos
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1982
Tipo de documento:
Article