Sulfonate analogues of adenosine nucleotides as inhibitors of nucleotide-binding enzymes.
J Med Chem
; 24(4): 474-7, 1981 Apr.
Article
em En
| MEDLINE
| ID: mdl-7021832
ABSTRACT
2-(Adenin-9-yl)ethanesulfonic acid (1), 3-(adenin-9-yl)propanesulfonic acid (2), 9-(5-deoxy-beta-D-ribofuranosyl)-adenine-5'-sulfonic acid (3), and 9-(3-deoxy-beta-D-arabinofuranosyl)adenine-3'-sulfonic acid (4) were prepared by reaction of the corresponding chlorides by sodium sulfite (1-3) or by reaction of an epoxide with sodium hydrogen sulfite (4). They inhibited a typical nucleotide-binding enzyme, horse liver alcohol dehydrogenase, with inhibition constants in the range of 0.18-4.9 mM at pH 8, 25 degrees C.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Sulfônicos
/
Nucleotídeos de Adenina
/
Oxirredutases do Álcool
/
Inibidores Enzimáticos
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1981
Tipo de documento:
Article