Human cell hybrids: analysis of transformation and tumorigenicity.
Science
; 215(4530): 252-9, 1982 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-7053574
ABSTRACT
Intraspecific human-human cell hybrids provide a stable model system with which to investigate the genetic control of transformed and tumorigenic phenotypes. Using this system it has been shown that these phenotypes are under separate genetic control. Furthermore, the tumorigenic phenotype can be complemented by fusion of different tumorigenic cells, resulting in nontumorigenic hybrids. This system also provides information on the control of differentiated function. Molecular cytogenetic techniques should reveal the nature of the chromosomal control of neoplastic transformation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Células Híbridas
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1982
Tipo de documento:
Article