Inhibitors of protein glycosylation inhibit the differentiation of Friend erythroleukemia cells.
Biochim Biophys Acta
; 696(3): 285-9, 1982 Mar 29.
Article
em En
| MEDLINE
| ID: mdl-7066327
ABSTRACT
Tunicamycin, 2-deoxy-D-glucose and 2-deoxy-2-fluoro-D-glucose inhibit dimethyl sulfoxide-induced differentiation of Friend cells. This inhibition, characterized by inhibition of hemoglobin synthesis, is accompanied by a specific inhibition of protein glycosylation. The results of cloning experiments indicate that this inhibition specifically affects cells in the period preceding their commitment. These results suggest that glycoprotein synthesis is a requirement for Friend erythroleukemia cells in order to initiate the expression of the terminal differentiation program.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas
/
Leucemia Experimental
/
Proteínas de Neoplasias
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1982
Tipo de documento:
Article