Evaluation of the 6-hour integrated concentration of cortisol as a diagnostic procedure for Cushing's syndrome.
J Clin Endocrinol Metab
; 54(5): 1072-4, 1982 May.
Article
em En
| MEDLINE
| ID: mdl-7199536
ABSTRACT
The diagnostic value of the 24-h integrated concentration (IC) test of cortisol (IC-24-F) was found to be superior to the value of both urinary 17OHCS and urinary free-cortisol tests. The IC-24-F test is too cumbersome for widespread clinical use. The purpose of the present study was to evaluate the diagnostic value of an abbreviated and practical 6-h IC of cortisol (IC-6-F) test. The IC of cortisol (IC-F) was measured in 68 normal subjects and 13 patients with surgically proven Cushing's syndrome. A portable nonthrombogenic constant blood withdrawal system was used over a 24-h period. The IC-F was measured in plasma withdrawn during each 1/2-h period (IC-1/2-F). The mean of 12 consecutive measurements of IC-1/2-F yielded the IC-6-F. The mean of all the IC-1/2-F collected over a 24-h period constituted the IC-24-F. The IC-1/2-F of the patients and their IC-6-F from 0800-1400 h, 1400-2000 h, and 2000-0200 h overlapped the corresponding levels in the control subjects. There was no overlap between the IC-24-F and the IC-6-F (from 2000-0200 h) of the patients and the control subjects. It was concluded that the diagnostic value of a 6-h IC-F test conducted during the afternoon and early part of the might is equal to the diagnostic value of the 24-h IC-F test.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrocortisona
/
Síndrome de Cushing
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
1982
Tipo de documento:
Article