Transformation of BHK 21/CL 13 cells by various polycyclic aromatic hydrocarbons using the method of Styles.
Toxicol Lett
; 7(2): 143-8, 1980 Dec.
Article
em En
| MEDLINE
| ID: mdl-7292524
ABSTRACT
Nine polycyclic aromatic hydrocarbons (PAHs) were investigated by the cell-transformation assay method of Styles. Benzo(a)pyrene [B(a)P], chrysene (CH), 3-methylcholanthrene (3-MC), benz(a)anthracene (BA), benzo(b)fluoranthene [B(b)F], and dibenz(a,h)anthracene (DBA) were tested, including liver homogenate, and showed dose-effect relationships and a more than 2-fold increase of transformation rates at LC50. Due to variations of the test method our results differed quantitatively from the data published by Purchase and Styles. Discrimination between the known carcinogens listed above and the noncarcinogens, phenanthrene (PA) and anthracene (AC), lacking a dose-effect relationship was, however, possible. Benzo(e)pyrene [B(e)P] was regarded as positive although producing only a 2-fold increase in the number of transformed colonies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Policíclicos
/
Carcinógenos
/
Transformação Celular Neoplásica
Limite:
Animals
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1980
Tipo de documento:
Article