Estrogen receptor and alpha-fetoprotein in human breast cancer: brief communication.
J Natl Cancer Inst
; 60(2): 289-90, 1978 Feb.
Article
em En
| MEDLINE
| ID: mdl-74414
ABSTRACT
Concentrations of estrogen receptor (ER) and alpha-fetoprotein were determined by dextran-coated charcoal assay and analyzed with Scatchard plots and radioimmunoassay, respectively, in cytosols of 72 human breast cancers. The values for ER ranged from 0 to 340 fmoles/mg cytosol protein. The concentrations of alpha-fetoprotein, which were low in all tumor cytosols examined, ranged from less than 0.1 to 1.1 ng/mg cytosol protein. No positive relationship was found between ER and alpha-fetoprotein concentrations. These results show that ER, but not alpha-fetoprotein, usually accounts for most of the high estrogen-binding capacity in cytosols of human breast cancers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Alfa-Fetoproteínas
/
Receptores de Estrogênio
Limite:
Female
/
Humans
Idioma:
En
Revista:
J Natl Cancer Inst
Ano de publicação:
1978
Tipo de documento:
Article