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Antibody response to polyribosyl-ribitol phosphate antigen of Haemophilus influenzae in Ecuadorian and German children.
Brüssow, H; Sidoti, J; Rytz, A.
Afiliação
  • Brüssow H; Nestlé Research Centre, Nestec Ltd., Lausanne, Switzerland.
Clin Diagn Lab Immunol ; 1(1): 21-5, 1994 Jan.
Article em En | MEDLINE | ID: mdl-7496916
Serum samples from 1,221 Ecuadorian children 0 to 5 years of age and from 236 German subjects were tested by enzyme-linked immunosorbent assay for class-specific antibodies to the capsular polysaccharide of Haemophilus influenzae type b (PRP antigen). A gradual prevalence increase of and mean titer increase in immunoglobulin M (IgM) antibody was seen in Ecuadorian but not in German children older than 6 months. At the end of the first year of life, about 50% of the Ecuadorian children showed IgM and IgG antibody to PRP. Seroepidemiological analysis revealed that living at a low altitude and lower calorie intake (a proxy measure of breast-feeding) were factors associated with earlier acquisition of PRP antibody. Children from low-altitude areas of Ecuador also experienced significantly more episodes of significant respiratory infections. The acquisition of PRP-reactive antibodies in Ecuadorian children might thus reflect exposure to encapsulated H. influenzae type b in lower respiratory tract infections.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Polissacarídeos Bacterianos / Haemophilus influenzae / Anticorpos Antibacterianos Tipo de estudo: Risk_factors_studies Limite: Child, preschool / Female / Humans / Infant / Male / Newborn País/Região como assunto: America do sul / Ecuador / Europa Idioma: En Revista: Clin Diagn Lab Immunol Assunto da revista: ALERGIA E IMUNOLOGIA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Polissacarídeos Bacterianos / Haemophilus influenzae / Anticorpos Antibacterianos Tipo de estudo: Risk_factors_studies Limite: Child, preschool / Female / Humans / Infant / Male / Newborn País/Região como assunto: America do sul / Ecuador / Europa Idioma: En Revista: Clin Diagn Lab Immunol Assunto da revista: ALERGIA E IMUNOLOGIA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Suíça