Synergy between tetrandrine and FK506 in prevention of diabetes in BB rats.
Life Sci
; 53(26): PL453-8, 1993.
Article
em En
| MEDLINE
| ID: mdl-7504774
ABSTRACT
Delayed administration of tetrandrine, a novel broad-spectrum anti-inflammatory agent, to BB rats at a dosage schedule of 20 mg kg-1 day-1 from 79 days of age reduced the cumulative incidence of diabetes from 73.1 to 41.7% (p < 0.01). Brief treatment with the potent immunosuppressive agent FK506 at a dosage schedule of 0.5 mg kg-1 day-1 from 79 days of age for 5 days had no significant effect on the cumulative incidence of diabetes (66.7%, p > 0.1). However, the combination of tetrandrine and FK506 in the afore-mentioned dosage schedules reduced the incidence of diabetes to only 3.6% (p < 0.001). These results suggest that the strong synergy between tetrandrine and FK506 may offer a safe and effective therapeutic strategy for the treatment of patients with recent onset or imminent IDDM.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ratos Endogâmicos BB
/
Anti-Inflamatórios não Esteroides
/
Tacrolimo
/
Benzilisoquinolinas
/
Diabetes Mellitus Tipo 1
/
Alcaloides
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1993
Tipo de documento:
Article