CpG islands and genes.
Curr Opin Genet Dev
; 5(3): 309-14, 1995 Jun.
Article
em En
| MEDLINE
| ID: mdl-7549424
Of the estimated 45,000 CpG islands in the human genome, the overwhelming majority are found at the 5' ends of genes and their identification and cloning are proving very useful for finding and isolating genes. Recent work has shed light on the chromosomal distribution and origin of CpG islands. It has been shown unequivocally that CpG islands are concentrated in the R band chromosomal regions and that intact transcription factor binding sites and required for their maintenance. Cases of methylation of CpG islands and inactivation of the associated genes have been reported which may be important in ageing, tumorigenesis and imprinting.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sequência de Bases
/
Genes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Assunto da revista:
GENETICA
Ano de publicação:
1995
Tipo de documento:
Article