Effects of C-terminal parathyroid hormone-related peptide on osteoblasts.
Miner Electrolyte Metab
; 21(1-3): 180-3, 1995.
Article
em En
| MEDLINE
| ID: mdl-7565445
ABSTRACT
A C-terminal analog of parathyroid hormone-related peptide (PTHrP), PTHrP(107-139), was found to stimulate cAMP production in three osteoblast cell preparations. The effect was studied most extensively in ROS 17/2.8 cells. The effect was dose-related and comparable in magnitude to that produced by PTHrP(1-34), but potency was lower. The functional significance of the cAMP effect is unknown, but preliminary findings indicated that PTHrP(107-139) also inhibited osteopontin mRNA levels in ROS 17/2.8 cells treated with peptide for 48 h. The results suggest that the carboxy-terminal region of PTHrP may play a role in bone metabolism by influencing osteoblast activity.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
/
Hormônio Paratireóideo
/
Fragmentos de Peptídeos
/
Proteínas
/
AMP Cíclico
/
Proteína Relacionada ao Hormônio Paratireóideo
Limite:
Animals
Idioma:
En
Revista:
Miner Electrolyte Metab
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos