[Serum determination of IgG, IgA, IgM, transferrin and haptoglobin. I. Attempt at normalization of results]. / Dosages sériques d'IgG, IgA, IgM, transferrine et haptoglobine. I. Essai d'harmonisation des résultats.
Ann Biol Clin (Paris)
; 53(5): 265-71, 1995.
Article
em Fr
| MEDLINE
| ID: mdl-7574114
This study demonstrates the advantages and limitations of normalizing results for five serum proteins (IgG, IgA, IgM, transferrin and haptoglobin), analysed in liquid phase on ten different systems (open clinical chemistry and dedicated protein analysers). Seven sets of results from normal and pathological sera (without monoclonal proteins) were compared using: - calibrators supplied by each manufacturer; - - serial dilutions of a single stabilized pool of liquid serum. In addition to validating the quality of the stabilised serum, we have been able to identify: - significant variations in results using different analytical systems for the same sample; - a major reduction in these variations, often greater than 50%, through normalization using a common serum pool. In some two thirds of the cases, this reduction brought the degree of variation into an acceptable range.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Análise Química do Sangue
/
Haptoglobinas
/
Imunoglobulinas
/
Transferrina
/
Imunoensaio
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Fr
Revista:
Ann Biol Clin (Paris)
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
França