Correlation of pharmacological properties of a group of beta-blocker agents by molecular topology.
J Pharm Pharmacol
; 47(3): 232-6, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-7602487
ABSTRACT
The molecular connectivity method has been applied to the study of pharmacological properties, among which are found the angor treatment dose, alpha-distribution half-life and intravenous LD50 in mouse, of a group of beta-blocker agents, verifying its application in the prediction of theoretic values for said pharmacological properties. To do this, the obtained multiple regression functions of the corresponding connectivity indices were used in relation with the experimental values of the properties, which are accompanied by the statistical parameters used in their selection criteria, as well as the corresponding random and cross-validation studies of said functions, which corroborate the good correlation of the selected equations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antagonistas Adrenérgicos beta
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Pharm Pharmacol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Espanha