Requirement of MIP-1 alpha for an inflammatory response to viral infection.
Science
; 269(5230): 1583-5, 1995 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-7667639
ABSTRACT
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
/
Citocinas
/
Monocinas
/
Enterovirus Humano B
/
Infecções por Orthomyxoviridae
/
Infecções por Coxsackievirus
/
Miocardite
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos