Morphological aspects of female Syrian hamster gallbladder induced by one-month sex steroid treatment.
J Submicrosc Cytol Pathol
; 27(1): 35-52, 1995 Jan.
Article
em En
| MEDLINE
| ID: mdl-7697621
ABSTRACT
Light (LM), transmission (TEM), and scanning (SEM) electron microscopy were used to characterize morphological changes induced in the gallbladder epithelium of female Syrian hamsters in response to one-month estradiol alone (E) and estradiol with medroxyprogesterone (E + MP) treatments. TEM data were correlated with the SEM observations. Compared with control (C), E- and E + MP-treated hamsters showed significant decreases in body weight, while the liver and gallbladder, and uterus weights increased. Moreover, E treatment induced some subcellular changes (microvilli, nucleus, mitochondria, RER, glycogen, abundant apical granules). The E + MP treatment appeared to exacerbate these similar changes and, in addition, induced apical excrescences and cell shedding. Both E and E + MP gallbladders showed luminal micelles, cellular debris and crystalliths associated with mucus. Simultaneously, an increased acidification of the mucoid content of the apical granules was noticed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estradiol
/
Vesícula Biliar
/
Medroxiprogesterona
Limite:
Animals
Idioma:
En
Revista:
J Submicrosc Cytol Pathol
Assunto da revista:
PATOLOGIA
Ano de publicação:
1995
Tipo de documento:
Article