Angiotensin(1-7) is an antagonist at the type 1 angiotensin II receptor.
J Hypertens
; 12(12): 1377-81, 1994 Dec.
Article
em En
| MEDLINE
| ID: mdl-7706697
ABSTRACT
OBJECTIVE:
The present study investigated the antagonism of the amino-terminal heptapeptide fragment of angiotensin II ([des-Phe8]-angiotensin II; Ang(1-7)) to angiotensin II (Ang II) both in vitro in rabbit aortae and in vivo in rats. METHODS ANDRESULTS:
In rabbit isolated endothelium intact aortic rings Ang(1-7) caused a concentration-related rightward displacement of the Ang II curve and depressed the maximum response to Ang II. By applying the data to a Schild plot an apparent pA2 of 5.5 was calculated. This depression of maximum response could be reversed by co-incubation of Ang(1-7) with the competitive angiotensin antagonist losartan. Ang(1-7) had no effect on the contractile responses of several other agonists. Intravenous infusion of 10 or 100 micrograms/kg per min Ang(1-7) had no effect on the resting blood pressure in the anaesthetized rat but inhibited Ang II-induced pressor responses.CONCLUSION:
The present results show that Ang(1-7) is a specific non-competitive antagonist of Ang II at type 1 angiotensin II receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Angiotensina II
/
Antagonistas de Receptores de Angiotensina
Limite:
Animals
Idioma:
En
Revista:
J Hypertens
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido