Unusually high affinity of Zn(II)-tetradibenzobarrelenooctabutoxy-phthalocyanine for low-density lipoproteins in a tumor-bearing mouse.
Photochem Photobiol
; 61(3): 310-2, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-7716192
ABSTRACT
An important factor in determining the efficacy of photosensitizing compounds in photodynamic therapy of tumors is the level to which tumors take up the photosensitizers after systemic injection. This parameter seems to be related to the transport modalities of the photosensitizer in the bloodstream. In this work the photosensitizer Zn(II)-tetradibenzobarrelenooctabutoxyphthalocyanine was shown to have an unprecedentedly high association with low-density lipoproteins (71% of the phthalocyanine in the plasma) when delivered in Cremophor micelles to tumor-bearing mice. This was accompanied by a particularly high tumor uptake at 24 h post-injection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Fármacos Fotossensibilizantes
/
Indóis
/
Lipoproteínas LDL
Limite:
Animals
Idioma:
En
Revista:
Photochem Photobiol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Itália