Sequential signalling during Caenorhabditis elegans vulval induction.
Nature
; 375(6527): 142-6, 1995 May 11.
Article
em En
| MEDLINE
| ID: mdl-7753169
ABSTRACT
During the induction of the Caenorhabditis elegans vulva, cell signalling causes initially equipotent cells to express a reproducible pattern of cell fates. The position of the anchor cell determines the pattern of vulval precursor cell fates, such that the closest precursor cell (P6.p) expresses the primary cell fate, the next closest cells (P5.p and P7.p) both express the secondary cell fate, and each of the precursor cells located at a distance (P3.p, P4.p and P8.p) express the tertiary cell fate (Fig. 1a). We present data indicating that this stereotypical pattern of cell fates can be generated by sequential signals. We identified genetic mosaic animals in which P5.p and P7.p were defective in the anchor-cell signal-transduction pathway and observed that these cells adopted the secondary cell fate, indicating that anchor-cell signal transduction is not required for the expression of the secondary cell fate. These results suggest that the anchor cell induces P6.p to express the primary cell fate, and that P6.p subsequently induces P5.p and P7.p to express the secondary cell fate.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vulva
/
Transdução de Sinais
/
Proteínas de Caenorhabditis elegans
/
Indução Embrionária
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nature
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos