[An immunomorphological study of the effect of ionizing radiation on the nonlymphoid structures of the mouse thymus using monoclonal antibodies]. / Immunomorfologicheskoe izuchenie vliianiia ioniziruiushchei radiatsii na nelimfoidnye struktury timusa myshei s pomoshch'iu monoklonal'nykh antitel.

ABSTRACT

Expression of cytoskeleton components revealed with monoclonal antibodies was increased in epithelial cells of mouse thymus one day after total gamma-irradiation with doses of 0.5-4.0 Gy, while after the doses of 10 and 15 Gy it was decreased. The antigen expression was reversed to initial level 14 days after the dose of 4 Gy; thymocyte depletion was progressed and continuous massifs of epithelial cells was formed. The oval cysts and immunoglobulin deposits were appeared in thymus two months after irradiation with the dose of 4 Gy.