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[Uptake of DL-3-123I-iodo-alpha-methyltyrosine in recurrent brain tumors]. / Anreicherung von DL-3-123I-Jod-alpha-methyltyrosin in Hirntumorrezidiven.
Guth-Tougelidis, B; Müller, S; Mehdorn, M M; Knust, E J; Dutschka, K; Reiners, C.
Afiliação
  • Guth-Tougelidis B; Klinik und Poliklinik für Nuklearmedizin des Universitätsklinikums Essen, FRG.
Nuklearmedizin ; 34(2): 71-5, 1995 Apr.
Article em De | MEDLINE | ID: mdl-7761277
ABSTRACT
DL-3-123I-iodo-alpha-methyltyrosine (123I-IMT) is a radiopharmacon which concentrates in brain tumors and can be employed in SPECT. We performed 20 studies in 16 patients after neurosurgery for malignant brain tumors (localization of the primary tumor by CT/MRI). Tumor/non-tumor ratios (T/NT) were calculated in ROI-technique. In 17 cases there was a recurrence or tumor remnant. 14/17 were detectable by increased uptake (T/NT 1.43-2.25). The scans were correlated with CT/MRI studies and validated by biopsy (6/14) or follow-up. All 3 patients without recurrence (neuroradiological follow-up over 6-24 months) had a negative scan. 123I-IMT scintigraphy provides complementary information to CT and MRI. In equivocal neuroradiological or clinical cases it may be valuable in the detection of tumor recurrences and allows an earlier onset of therapy.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Radioisótopos do Iodo / Metiltirosinas Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans Idioma: De Revista: Nuklearmedizin Ano de publicação: 1995 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Radioisótopos do Iodo / Metiltirosinas Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans Idioma: De Revista: Nuklearmedizin Ano de publicação: 1995 Tipo de documento: Article