[Expression of WT1mRNA: relation to histology in Wilm's tumor].
Zhonghua Wai Ke Za Zhi
; 32(12): 712-4, 1994 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-7774415
ABSTRACT
UNLABELLED The mRNA expression of WT1 gene was examined by Northern blot and Dot blot hybridization in 13 Wilm's tumors of varying histology, 2 normal kidneys (1 and 5 years of age) and 1 fetal kidney (5 months of gestation). RESULTS:
(1) WT1 gene expression was much higher in fetal kidney than in normal kidney of children; (2) Wilm's tumors which were predominantly epithelial or blastemal expressed high amounts of WT1mRNA, whereas predominantly stromal tumors expressed low amounts (P < 0.01). The data suggests that (1) there is a relationship between WT1 gene expression and cellular differentiation in kidney development; (2) low level expression of WT1mRNA results in disruption of cell differentiation and development of Wilms' tumor which shows stromal-predominant histology.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Genes do Tumor de Wilms
/
Tumor de Wilms
/
Neoplasias Renais
Limite:
Child
/
Child, preschool
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Female
/
Humans
/
Infant
/
Male
Idioma:
Zh
Revista:
Zhonghua Wai Ke Za Zhi
Ano de publicação:
1994
Tipo de documento:
Article