Pharmacological differentiation of the effects of co-activation of beta-adrenergic and metabotropic glutamate receptors in rat hippocampus.
Neurosci Lett
; 186(2-3): 119-22, 1995 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-7777178
ABSTRACT
Activation of metabotropic glutamate receptors (mGluRs) can potentiate the cAMP response elicited by activation of beta-adrenergic receptors (beta ARs) in the hippocampus. We have shown that co-activation of mGluRs and beta ARs induces both an acute depression of excitatory synaptic transmission and a long-lasting excitation of CA1 pyramidal cells. However, these studies were performed using a non-selective mGluR agonist. We have now used subtype selective mGluR agonists, and report that while the acute depression of transmission exhibits a pharmacology consistent with mediation by this mGluR subtype, the lasting excitation of CA1 pyramidal cells may be mediated by an interaction between beta ARs and mGluRs that are coupled to phosphoinositide hydrolysis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Adrenérgicos beta
/
Receptores de Glutamato Metabotrópico
/
Agonistas Adrenérgicos beta
/
Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos