Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion.
Neurosci Lett
; 186(2-3): 99-102, 1995 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-7777208
ABSTRACT
A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (< or = 1 week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-D-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]alpha-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Núcleos Talâmicos
/
Gânglios da Base
/
NAD(P)H Desidrogenase (Quinona)
/
Receptores de Glutamato
/
Mitocôndrias
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Itália