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Is neuro-ectodermal differentiation of Ewing's sarcoma of bone associated with an unfavourable prognosis?
Terrier, P; Henry-Amar, M; Triche, T J; Horowitz, M E; Terrier-Lacombe, M J; Miser, J S; Kinsella, T J; Contesso, G; Llombart-Bosch, A.
Afiliação
  • Terrier P; Département d'Anatomie Pathologique, Institut Gustave Roussy, Villejuif, France.
Eur J Cancer ; 31A(3): 307-14, 1995.
Article em En | MEDLINE | ID: mdl-7786593
Among Ewing's sarcoma (ES) of bone and related entities are tumours with neuro-ectodermal features that could represent a biologically distinct type. In order to assess the prognostic significance of the various forms of ES, a retrospective joint study involving three cancer centres in Europe and the U.S.A. was initiated. The material from 315 primary ES was reviewed by a panel of five pathologists and classified as typical ES (220 cases), atypical ES (48 cases) or ES with neuro-ectodermal features (47 cases). Prognostic factor analysis on treatment failure-free survival was performed using the Cox model. It included histopathological classification, initial patient characteristics, clinical presentation and treatment type. After multivariate analysis, in addition to treatment type (P < 0.001), metastases (P = 0.003) and proximal tumour location (P = 0.006), two histopathological parameters correlated with poor treatment failure-free survival, the presence of filigree pattern (P = 0.044) and dark cells (P = 0.043). We conclude that ES with neuro-ectodermal features does not appear to have a different outcome to the other subtypes.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma de Ewing / Neoplasias Ósseas / Tumores Neuroectodérmicos Primitivos Periféricos Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Eur J Cancer Ano de publicação: 1995 Tipo de documento: Article País de afiliação: França
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma de Ewing / Neoplasias Ósseas / Tumores Neuroectodérmicos Primitivos Periféricos Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Eur J Cancer Ano de publicação: 1995 Tipo de documento: Article País de afiliação: França