Effects of low level lead exposure on behavior of young rats.

ABSTRACT

Dam rats were given Pb (0.58, 1.76, and 5.27 mmol.L-1), containing water ad lib from d 16 of gestation to weaning of the offspring on d 21 postpartum. The pups continued drinking the same water till the postnatal d 30. The neurobehavioral function of pups was tested. The second step-down latencies (SDL2) were shortened and the number of step-downs in 5 min (NSD) were increased in step-down test. The prolongation of the lapse of time in passing through the whole course (LTPWC) and the increase in number of entries into the blind alley (NEBA) were measured in water maze test. The number of ambulations and rearings were increased in locomotor activity. The results indicated that Pb exerts adverse effects on the learning ability and memory function, and induces hyperactivity in young rats.