Immunomodulatory effect of sodium dodecyl sulfate on human neutrophils and the human promyelocytic HL-60 cell line.
Eur J Pharmacol
; 270(4): 285-9, 1994 Aug 03.
Article
em En
| MEDLINE
| ID: mdl-7805777
ABSTRACT
The effect of sodium dodecyl sulfate (SDS), an anionic amphiphilic detergent, on the function of human neutrophils and of the human promyelocytic leukemia cell line HL-60 was investigated. SDS modulated the respiratory burst in human neutrophils and HL-60 cells which were stimulated with phorbol 12-myristate 13-acetate (PMA). In concentrations above 1 X 10(-6) M it also caused release of lysosomal enzymes (beta-D-glucuronidase, myeloperoxidase and lysozyme) from neutrophils. Our results demonstrate that SDS at concentrations 1 X 10(-6) M-1 X 10(-4) M strongly affect properties of human phagocytic cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dodecilsulfato de Sódio
/
Leucemia Mieloide
/
Adjuvantes Imunológicos
/
Neutrófilos
Limite:
Humans
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1994
Tipo de documento:
Article