Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient.
Leukemia
; 8(12): 2224-7, 1994 Dec.
Article
em En
| MEDLINE
| ID: mdl-7808011
ABSTRACT
A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 11
/
Rearranjo Gênico
/
Leucemia Monocítica Aguda
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Leukemia
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
França