Analysis of the age-related composition of human skin collagen and collagens synthesized by fibroblast culture.
Arch Dermatol Res
; 286(7): 391-5, 1994.
Article
em En
| MEDLINE
| ID: mdl-7818281
ABSTRACT
Age-related differences in the composition and the post-translational modifications of human skin collagens were examined in the present study. The data were compared with results of collagen synthesis from in vivo-aged fibroblasts in culture. Skin extracts and newly synthesized collagen from fibroblast cultures derived from both old and young donor groups showed the same ratio of collagen III to collagen I. Furthermore, no difference was noted in the degree of prolyl and lysyl hydroxylation of collagen I and collagen III Young and old fibroblasts synthesized a similar quantity of collagen in vitro. The data suggest that fibroblasts maintain a uniform level of collagen production, composition and modification independent of the age of the donor.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Envelhecimento
/
Colágeno
/
Fibroblastos
Limite:
Adult
/
Aged
/
Humans
Idioma:
En
Revista:
Arch Dermatol Res
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Alemanha