Production and characterization of monoclonal antibodies directed against high and low molecular weight kininogens.
Bull Soc Sci Med Grand Duche Luxemb
; 131(2): 9-17, 1994.
Article
em En
| MEDLINE
| ID: mdl-7820912
ABSTRACT
HMWK and LMWK were purified from human plasma by ion exchange and affinity chromatography and used to raise anti-kininogen monoclonal antibodies. The Ig class and affinity of these Mab's that are directed at the heavy chain of the kininogens, were determined. Plasma samples of two patients, one with acquired C1-inhibitor deficiency and angioedema and one with idiopathic angioedema were analized by immunoblotting with these Mab's. Both were found to have cleaved HMWK during clinical attacks.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cininogênios
/
Anticorpos Monoclonais
Limite:
Humans
Idioma:
En
Revista:
Bull Soc Sci Med Grand Duche Luxemb
Ano de publicação:
1994
Tipo de documento:
Article