[Significance of histologic bone marrow evaluation in diagnosis of chronic granulocytic leukemia. I. Reticulin fibrosis]. / Znaczenie oceny histologicznej szpiku w diagnostyce przewleklej bialaczki szpikowej. I. Wlóknienie retikulinowe.

ABSTRACT

The aim of the study was the evaluation of bone marrow reticulin fibrosis in non-treated patients suffering from chronic granulocytic leukaemia (cgl). We have examined 40 patients (19 female and 21 male, average age 41.2 years) with chronic phase, Ph'-positive cgl. Reticulin fibrosis grade I and II (according to Dekmezian and co.) was detected in 47.5% of patients and grade III and IV in 42.5%. Statistically significant correlation was found between reticulin fibrosis intensity and spleen size, platelets count and Sokal index. We believe that reticulin fibrosis assessment is of prognostic value.