Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.
J Thorac Cardiovasc Surg
; 109(2): 236-41, 1995 Feb.
Article
em En
| MEDLINE
| ID: mdl-7853876
ABSTRACT
Transgenic mice with intense cardiac expression of a human beta-adrenergic receptor gene were engineered and shown to display marked improvements in baseline myocardial and left ventricular function. Heart/body weight ratios and histologic appearance were not found to be significantly altered, suggesting that receptor gene expression did not induce pathologic changes. Given the substantial reduction in beta-adrenergic receptor density and resultant reduction in inotropic responsiveness observed in chronic heart failure, these findings represent a novel approach for increasing myocardial function with important clinical implications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Função Ventricular Esquerda
/
Receptores Adrenérgicos beta 2
/
Contração Miocárdica
/
Miocárdio
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Thorac Cardiovasc Surg
Ano de publicação:
1995
Tipo de documento:
Article