Your browser doesn't support javascript.
loading
Interleukin-1 beta dissociates beta-amyloid precursor protein and beta-amyloid peptide secretion.
Vasilakos, J P; Carroll, R T; Emmerling, M R; Doyle, P D; Davis, R E; Kim, K S; Shivers, B D.
Afiliação
  • Vasilakos JP; Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Co., Ann Arbor, MI 48105.
FEBS Lett ; 354(3): 289-92, 1994 Nov 14.
Article em En | MEDLINE | ID: mdl-7957941
A heightened production of interleukin 1 beta (IL-1 beta) has been reported in microglial-associated amyloid deposits in Alzheimer's disease (AD) brains. These plaques are composed predominantly of beta/A4 peptide derived from beta-amyloid precursor protein (beta APP). We demonstrate that short-term (1 h) IL-1 beta-treatment increases beta APPs secretion and concomitantly decreases cell-associated beta APP in human H4 neuroglioma cells. Long-term (5 h) IL-1 beta treatment did not alter secreted or cell-associated beta APP content. In contrast, the secretion of beta/A4-containing epitope was not affected by short-term IL-1 beta stimulation; however, long-term IL-1 beta treatment decreased the amount of beta/A4-containing epitope secreted from the cells. These results show that IL-1 beta modifies the processing and secretion of beta APP to exacerbate perhaps the neuropathology of AD.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Interleucina-1 / Precursor de Proteína beta-Amiloide Limite: Humans Idioma: En Revista: FEBS Lett Ano de publicação: 1994 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Interleucina-1 / Precursor de Proteína beta-Amiloide Limite: Humans Idioma: En Revista: FEBS Lett Ano de publicação: 1994 Tipo de documento: Article