The human placental immunoglobulin G receptor and immunoglobulin G transport.
Am J Obstet Gynecol
; 171(1): 258-63, 1994 Jul.
Article
em En
| MEDLINE
| ID: mdl-8030710
ABSTRACT
OBJECTIVE:
The objective of this study was to quantitatively determine an immunoglobulin G receptor, placental alkaline phosphatase, and its ligand immunoglobulin G in maternal and fetal blood and to study the transport capacity of the receptor. STUDYDESIGN:
Venous blood samples from 66 term pregnant women and cord samples from their fetuses were obtained, together with the corresponding placentas.RESULTS:
Mean placental alkaline phosphatase levels were determined to be 23.7 ng/ml and 1.2 ng/ml in maternal and fetal blood, respectively. Mean immunoglobulin G level of the fetal samples was significantly higher than that of the maternal samples (12.6 vs 9.5 gm/L, p < 0.0001). The placental alkaline phosphatase phenotype S had a larger dissociation constant to immunoglobulin G than did type F and was found to have mean fetal immunoglobulin G levels higher than those of the F type (13.3 vs 9.7 gm/L).CONCLUSION:
The placental immunoglobulin G receptor placental alkaline phosphatase is found in the fetal circulation. The placental alkaline phosphatase phenotype was found to be related to the levels of its ligand immunoglobulin G in fetal blood, although the mechanism for this remains to be established. Immunoglobulin G is actively transported to fetal blood to reach higher levels than in the maternal circulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Imunoglobulina G
/
Gravidez
/
Fosfatase Alcalina
/
Sangue Fetal
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Suécia