Psoriasin binds calcium and is upregulated by calcium to levels that resemble those observed in normal skin.
J Invest Dermatol
; 103(3): 370-5, 1994 Sep.
Article
em En
| MEDLINE
| ID: mdl-8077703
ABSTRACT
Recently, we described a small molecular weight protein termed psoriasin that showed sequence similarity with the S100 calcium-binding proteins and that is highly upregulated in psoriatic epidermis as well as in primary human keratinocytes undergoing abnormal differentiation. Here we present evidence showing that natural and recombinant psoriasin binds calcium, as judged by the calcium overlay assay, and that it contains all the sequence features characteristic of the S100 family. Furthermore, [35S]-methionine labeling experiments showed that psoriasin synthesis is upregulated by 2 mM Ca++ (ratio Ca++/control at 88 h = 2.56) to levels that resemble those observed in unfractionated keratinocyte populations obtained from normal skin.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Proteínas de Ligação ao Cálcio
/
Cálcio
Limite:
Humans
Idioma:
En
Revista:
J Invest Dermatol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Dinamarca