Intravenous injection of allogeneic cells can prime T-lymphocytes with cytotoxic activity.
Immunol Lett
; 35(1): 13-8, 1993 Jan.
Article
em En
| MEDLINE
| ID: mdl-8096201
ABSTRACT
The possibility of specific cytotoxic T-lymphocyte (CTL)2 induction was shown upon intravenous (i.v.) immunization of mice with 9 x 10(7) irradiated (2000 rad) allogeneic splenocytes. The induced CTL express the cell surface markers Thy1.2+, L3T4- and Lyt2+. No correlation between the level of cytotoxic activity and the ability to inhibit proliferation was shown in populations of lymphocytes, primed both by i.v. immunization and in mixed lymphocyte culture (MLC). The possible role of cytotoxic activity in down-regulation of the immune response is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
/
Isoantígenos
Limite:
Animals
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Federação Russa