Tissue distribution of 3H-terbutaline in rabbits.
Life Sci
; 54(20): 1465-9, 1994.
Article
em En
| MEDLINE
| ID: mdl-8190021
ABSTRACT
Terbutaline is a widely used, selective beta 2-adrenergic agonist whose penetration into brain has not been demonstrated in laboratory animals. Although its tissue uptake has been reported in some animals, no uptake into brain has been demonstrated. A single dose of 20 microCi of 3H-terbutaline along with 10 mg/kg of unlabeled terbutaline was injected into a rabbit marginal ear vein. The distribution of 3H-terbutaline in several tissues was determined 0.5, 1, 3, or 6 hr later. Radioactivity in the brain was well-maintained over the 6 hr observation period. In most tissues, radioactivity peaked in less than 1 hr, then declined. Radioactivity in the urine was high at all time periods and was highest at 3 hr. Thus, terbutaline or a metabolite(s) does cross the blood-brain barrier in rabbits, and the radioactivity in the rabbit brain does not decrease during the 6 hours following terbutaline injection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terbutalina
/
Encéfalo
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1994
Tipo de documento:
Article