Yeast aspartyl-tRNA synthetase: a structural view of the aminoacylation reaction.
Biochimie
; 75(12): 1117-23, 1993.
Article
em En
| MEDLINE
| ID: mdl-8199247
ABSTRACT
The refinement of the crystal structure of a binary complex formed by yeast AspRS and tRNA(Asp) provided a detailed understanding of the recognition of tRNA by an aminoacyl-tRNA synthetase. The crystal structures of several complexes containing ATP, alone or with aspartic acid, were also determined and refined. These studies led to a complete description of the active site of the enzyme and to the elucidation of the location and interactions of the various substrates. Based on these structural results, a class II-specific pathway for the aminoacylation reaction can be proposed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aspartato-tRNA Ligase
/
Leveduras
Idioma:
En
Revista:
Biochimie
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
França