Neuropeptide Y in the arcuate nucleus is modulated by alterations in glucose utilization.
Brain Res
; 621(2): 343-8, 1993 Sep 10.
Article
em En
| MEDLINE
| ID: mdl-8242347
ABSTRACT
This study examined the response of hypothalamic neuropeptide Y (NPY) to specific metabolic challenges. After intraperitoneal administration of 2-deoxy-D-glucose, which blocks glucose utilization, NPY levels measured via radioimmunoassay were significantly potentiated in the arcuate (ARC) and suprachiasmatic nuclei of the rat hypothalamus. The antimetabolite mercaptoacetate, in contrast, which blocks fatty acid oxidation, produced no significant change and actually tended to reduce NPY levels in the ARC. It is concluded that glucose utilization, in particular, may constitute an important signal, either direct or indirect, in the modulation of NPY production in the hypothalamus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeo Y
/
Núcleo Arqueado do Hipotálamo
/
Glucose
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1993
Tipo de documento:
Article